Zinedine Zidane will be without a host of first-team players, including Karim Benzema and Sergio Ramos, when his side take on Villarreal.
Real Madrid have not yet agreed a new contract with Sergio Ramos, and Zinedine Zidane wants to see the situation addressed quickly.
Lionel Messi continues to be linked with Pep Guardiola's Manchester City.
Real Madrid will take on Villarreal, Inter and Deportivo Alaves without captain Sergio Ramos, according to the Spanish media.
Manchester City are reportedly eyeing a move for Lionel Messi in the New Year.
Spain boss Luis Enrique hailed a flawless display from his side against Germany, plus provided an update on Sergio Ramos.
Germany needed just a draw with Spain to qualify from their Nations League group, but they were resoundingly beaten in Seville.
Spain lost Sergio Canales and Sergio Ramos to apparent hamstring problems in the first half of their Nations League match with Germany.
Javier Tebas hopes Lionel Messi and Sergio Ramos remain in LaLiga, but is confident the competition can prosper without them.
Renewals for Kylian Mbappe and Neymar are the focus for Paris Saint-Germain.